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Jul 12 Issue

Making cancer drugs from natural food
Preparation of anti-tumor nanoparticles using tiger milk mushroom...

Cancer is a word dreaded by many. Many cancers are deadly and difficult to treat while conventional remedies such as chemotherapy often cause physical and emotional sides effects, giving struggling patients more harm just as the cancer. What if cancer-killing drugs can become more natural and in harmony with our body? Tapping into the power of natural ingredients for safer treatment is the next frontier in the battle against cancer. A recent breakthrough from PolyU’s Department of Applied Biology and Chemical Technology using tiger milk mushroom to prepare anti-tumor nanoparticles is bringing us one step closer.

A natural compound found in mushrooms may hold the key to a new class of cancer drugs. In Tiger Milk mushrooms from Africa, Dr Wong Ka-hing, Associate Director of the Food Safety and Technology Research Centre, has discovered a polysaccharide-protein complex (PSP) which can turn selenium, a common nutrient, into new cancer therapy to benefit millions of breast cancer patients around the world. 

Selenium is a trace mineral essential for good health. Health benefits include boosting immune systems against viral infections. Staple foods and vegetables in our diet such as rice, wheat, potatoes, broccolis and onions are great sources of antioxidant. In nano-size, selenium was found to have potent anti-cancer effect in the laboratory. However, efficacy diminished as the nanoparticles fell back into bigger aggregates which suppressed the up-take into cancer cells. Finding new ways or compounds to halt the rebinding process is harder than it seems. Literally, it is quite like searching for a needle in a haystack. 

The use of mushroom PSP as stabilizing force is a significant breakthrough. Combined with cutting-edge nanotechnology, Dr Wong and his team successfully made selenium nanoparticles to destroy breast cancer cells. “Lab-test results were exciting. Our selenium nanoparticles were found to have remarkable inhibition effect on the growth of human breast cancer cells by triggering the cells into self-destruction. The next stage will be tests on animals,” Dr Wong said.

The research is still in a very early phase. But if successful, it could lead to a new drug much less toxic and more reliable, capable of killing cancer cells while leaving healthy tissues unharmed, which could mean fewer agonizing side-effects, greater comfort and better chances of recovery. Dr Wong also planned on developing a dietary supplement as auxiliary cancer treatments.

Scientists around the world have been looking into the therapeutic value of produces such as fish oil, broccoli, cauliflower, cabbage, and green tea. For safe human consumption, a natural ingredient must be effective against cancer in low concentration. Dr Wong’s work has advanced medicine with a working tool for boosting the effectiveness of natural cancer killing compounds.

“Mushroom PSP has striking effects on controlling selenium nanoparticles,” Dr. Wong added, “and a better understanding of this mechanism may help us find the next suitable compounds and make better nano-medicines for a whole host of cancers.” Tiger Milk, similar to Chinese mushrooms we have in dishes and soups mushroom, is a common foodstuff in Africa, and the groundbreaking biomedical research opens door to making cancer drug from 100% natural ingredients. The drug development process is equally natural and green because all it takes are room temperature and water, which is little waste and without much power consumption.

Holding new promise for beating cancer, this research has won Dr Wong the Young Investigator Award at the 2011 International Conference of Food Factors and the Gold Medal in 40th International Exhibition of Inventions of Geneva. These prestigious awards were at the same time an endorsement to the long-running commitment from the University to the discovery and development of ingredients for the betterment of the community.



       

 
A polysaccharide-protein complex was found in Tiger Milk mushrooms from Africa, which can turn selenium into new cancer treatment 虎奶菇能把食物中一種常見的營養成分硒,變成對抗人類乳癌的有效武器


Preparation of highly stable SeNPs under a simple food-grade, environmentally friendly redox system 利用簡單的食品級氧化還原體系製備高穩定性SeNPS





This cutting-edge technology has won prestigious awards at the 2011 International Conference of Food Factors and the 40th International Exhibition of Inventions of Geneva 這項突破性的科研成果於2011國際食品保健因子大會及第40屆日內瓦國際發明展榮獲國際殊榮